Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis
These results demonstrate that TBX18 in SMCs is essential not only for normal aortic development, but also for preventing gene expression programmes linked to adverse remodelling in adulthood. These findings enhance our understanding of the function of this transcription factor and of molecular mechanisms underlying aneurysm formation, a pathology responsible for a significant number of fatalities in developed countries.
Authors
- Sofia Peruzzo (ORCID: https://orcid.org/0000-0003-0008-6361)
- Nadja Sachs (ORCID: https://orcid.org/0000-0001-8031-017X)
- Jaroslav Pelisek (ORCID: https://orcid.org/0000-0002-8951-132X)
- Stefanie Dimmeler (ORCID: https://orcid.org/0000-0002-1045-2436)
- Francesca Andriani (ORCID: https://orcid.org/0000-0002-6178-7789)
- Lars Mäegdefessel (ORCID: https://orcid.org/0000-0001-5228-2634)
- Yusu Gu (ORCID: https://orcid.org/0000-0002-9543-8472)
- Jody Martin (ORCID: https://orcid.org/0000-0002-1421-4179)
- Sara Rega
- Ariane Fischer
- Veronica Larcher (ORCID: https://orcid.org/0000-0002-4398-7058)
- Carsten Kuenne (ORCID: https://orcid.org/0000-0001-8013-5906)
- Sylvia Μ. Evans (ORCID: https://orcid.org/0000-0001-5035-3697)
- Mattia Chiesa (ORCID: https://orcid.org/0000-0001-7427-9954)
- Stefan Günther (ORCID: https://orcid.org/0000-0002-5594-4549)
- Hanna Winter (ORCID: https://orcid.org/0000-0001-8110-8627)
- Gianluca Lorenzo Perrucci (ORCID: https://orcid.org/0000-0002-4758-6040)
- Emanuele Pizzo (ORCID: https://orcid.org/0000-0002-0336-688X)
- Nuno Guimarães‐Camboa (ORCID: https://orcid.org/0000-0001-5349-4604)
- Paola Cattaneo (ORCID: https://orcid.org/0000-0001-9987-5285)
- Debanjan Mukherjee (ORCID: https://orcid.org/0000-0002-0788-6460)
- Kirk L. Peterson
Institutions
- Goethe University Frankfurt (DE)
- Goethe-Institute United Kingdom (GB)
- University of Freiburg (DE)
- University of Milan (IT)
- TUM Klinikum (DE)
- University of California San Diego (US)
- Centro Cardiologico Monzino (IT)
- University Hospital of Zurich (CH)
- Max Planck Institute for Heart and Lung Research (DE)
- Institute of Genetic and Biomedical Research (IT)
- German Centre for Cardiovascular Research (DE)
- La Jolla Bioengineering Institute (US)
- National Research Council (IT)
- University of Montana (US)
- Politecnico di Milano (IT)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1093/cvr/cvaf201
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00