Suppression of NK cell-mediated immunosurveillance by IL-35 drives tumor progression in EGFR-mutant non-small cell lung cancer
IL-35 is upregulated in EGFR-mutant NSCLC and mediates immune suppression by impairing NK cell activity. Targeting IL-35 may offer a therapeutic avenue to restore NK cell function and enhance anti-tumor immunity.
Authors
- Hui Wang (ORCID: https://orcid.org/0009-0005-6936-9281)
- Daqing Wang (ORCID: https://orcid.org/0000-0002-4576-6734)
- Fengju Zhou
- Yinsong Zhang
- Na Li (ORCID: https://orcid.org/0009-0001-8624-0114)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7111-7164)
- Xiaojie Zhang (ORCID: https://orcid.org/0000-0001-9850-9806)
- Fang Yang (ORCID: https://orcid.org/0000-0003-0688-5690)
Institutions
- Hebei Medical University (CN)
- Hengshui University (CN)
- First Hospital of Shijiazhuang (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fonc.2025.1692801
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00