APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer’s disease
Our findings demonstrate a link between tau accumulation and astrocyte-mediated neuroinflammation in AD and highlight the modulatory role of APOE ε4 in this process. Taken together, our findings help inform the multifaceted role of tau-associated neuroinflammation in the progression of AD.
Authors
- Yasser Iturria‐Medina (ORCID: https://orcid.org/0000-0002-9345-0347)
- Chris Hsiao (ORCID: https://orcid.org/0009-0009-2062-3516)
- Serge Gauthier (ORCID: https://orcid.org/0000-0003-4272-3330)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- João Pedro Ferrari‐Souza (ORCID: https://orcid.org/0000-0003-2183-1551)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-8953-1542)
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Jesse Klostranec (ORCID: https://orcid.org/0000-0003-3553-0530)
- Marcel S. Woo (ORCID: https://orcid.org/0000-0002-1306-2708)
- Jaime Fernandez‐Arias
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Andréa Lessa Benedet (ORCID: https://orcid.org/0000-0001-8219-1741)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Brandon J. Hall (ORCID: https://orcid.org/0009-0007-4578-2033)
- Seyyed Ali Hosseini (ORCID: https://orcid.org/0000-0001-7542-7541)
- Stijn Servaes (ORCID: https://orcid.org/0000-0003-3565-1930)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Yi‐Ting Wang (ORCID: https://orcid.org/0000-0002-9130-5461)
- Maxime Montembeault (ORCID: https://orcid.org/0000-0002-9369-0498)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- Yansheng Zheng
- Étienne Aumont (ORCID: https://orcid.org/0000-0002-8997-7090)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
Institutions
- University of Science and Technology of China (CN)
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- University of Wisconsin–Madison (US)
- Universität Hamburg (DE)
- University of Pittsburgh (US)
- King's College London (GB)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- McGill University Health Centre (CA)
- Centre for Mental Health (GB)
- Sorbonne Université (FR)
- Southwestern Medical Center (US)
- University Medical Center Hamburg-Eppendorf (DE)
- McGill Genome Centre (CA)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- McGill University (CA)
- The University of Texas Southwestern Medical Center (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1038/s43856-025-01171-4
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Alzheimer's Association
- Fondation Brain Canada
- Weston Brain Institute
- Consortium canadien en neurodégénérescence associée au vieillissement
- European Commission
- Vetenskapsrådet
- HORIZON EUROPE Framework Programme
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé