Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities
Several factors in acromegaly may affect brain structure, promoting WMH development, such as aging, disease duration, and hypertension. Therefore, in patients with acromegaly, we suggested the early management of cardiovascular comorbidities and regular radiological follow-up, not limited to the study of the pituitary gland. Future prospective studies are necessary to confirm our preliminary observations and to clarify the potential role of disease activity and treatment in WMH development.
Authors
- Valeria Mercuri (ORCID: https://orcid.org/0000-0002-0158-2116)
- Patrizia Gargiulo (ORCID: https://orcid.org/0000-0003-1216-2034)
- Vittorio Di Piero (ORCID: https://orcid.org/0000-0002-2631-7562)
- Camilla Virili (ORCID: https://orcid.org/0000-0002-4973-1950)
- Chiara Pellicano (ORCID: https://orcid.org/0000-0003-1077-4846)
- Valentina Martines
- Giada Giuliani (ORCID: https://orcid.org/0000-0001-5910-6043)
- Diego Silveira da Costa (ORCID: https://orcid.org/0000-0002-9583-853X)
Institutions
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1111/cen.70057
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00