RE-Aging, A Functional Analysis Platform for Human RNA Editing Associated with Aging
RNA editing alters mRNA sequences and is linked to aging. We introduce RE-Aging, a platform analyzing age-related RNA editing using GTEx data (259,620 A-to-I and 30,502 C-to-U sites across 27 tissues). Features include site exploration, age correlations, gene annotation, RNA structure analysis, and miRNA binding impact. Supports differential editing analysis (Wilcoxon test) and single-cell RNA editing age mapping for blood cells. Access at http://bioinfo-sysu.com/RE-Aging/.
Authors
- Xinghua Pan (ORCID: https://orcid.org/0000-0002-7421-8155)
- Zhou Songyang
- Yuanyan Xiong (ORCID: https://orcid.org/0000-0002-3227-5215)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-6597-8910)
- Weiwen Huang
- Wenbin Ma (ORCID: https://orcid.org/0000-0001-8774-7593)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Molecules and Cells
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.mocell.2025.100300
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00