Endothelial dysfunction and cardiovascular outcomes in pre-menopausal women with high vs low breast fat accumulation: The role of TSP-1
Women with High-BFA vs Low-BFA showed higher rates of ED and MACE, along with increased inflammatory/oxidative markers and elevated ET-1 and TSP-1 levels. TSP-1 independently predicted both ED (HR 1.081) and MACE (HR 1.170). ET-1 levels predicted greater risk of MACE (HR 1.459). High BFA (HR 1.65) and impaired FMD (HR 1.189) independently predicted MACE at 5 years.
Authors
- Michelangela Barbieri (ORCID: https://orcid.org/0000-0002-9223-5792)
- Francesco Iovino (ORCID: https://orcid.org/0000-0002-3718-5809)
- Giuseppe Signoriello (ORCID: https://orcid.org/0000-0002-6609-2708)
- Gianluca Gatta (ORCID: https://orcid.org/0000-0003-0874-8294)
- Carmine Pizzi (ORCID: https://orcid.org/0000-0002-4048-675X)
- Raffaele Marfella (ORCID: https://orcid.org/0000-0003-3960-9270)
- Ludovica Vittoria Marfella
- Gorizio Pieretti
- Maria Luisa Balestrieri (ORCID: https://orcid.org/0000-0001-6001-1789)
- Daniele La Forgia (ORCID: https://orcid.org/0000-0002-3902-4523)
- Donna L. Cioffi (ORCID: https://orcid.org/0000-0002-8833-128X)
- Maria Consiglia Trotta (ORCID: https://orcid.org/0000-0001-9813-5955)
- Roberto Grella (ORCID: https://orcid.org/0000-0001-8555-785X)
- Giuseppe Paolisso (ORCID: https://orcid.org/0000-0002-2137-455X)
- Celestino Sardu (ORCID: https://orcid.org/0000-0001-5099-3790)
- Giovanni Francesco Nicoletti (ORCID: https://orcid.org/0000-0003-4586-0314)
- Nunzia D’ Onofrio
- Salvatore Cappabianca
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Istituto Tumori Bari (IT)
- University of Bologna (IT)
Publication Details
- Journal
- American Journal of Preventive Cardiology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ajpc.2025.101349
- Citations
- 1
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29