Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit
Human spaceflight is advancing toward sustainable exploration through initiatives like NASA's Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome-integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.
Authors
- Rik Olde Engberink (ORCID: https://orcid.org/0000-0002-3177-2279)
- Tobias Weber (ORCID: https://orcid.org/0000-0002-3015-3468)
- Anna‐Maria Liphardt (ORCID: https://orcid.org/0000-0003-0739-1959)
- Olivier White (ORCID: https://orcid.org/0000-0002-1411-6667)
- Monica Monici (ORCID: https://orcid.org/0000-0001-6678-9241)
- Laurence Vico
- Nandu Goswami (ORCID: https://orcid.org/0000-0002-6704-0723)
- Stefan Schneider (ORCID: https://orcid.org/0000-0002-6903-6605)
- Dieter Blottner (ORCID: https://orcid.org/0000-0003-0355-3340)
- Claudia Stern (ORCID: https://orcid.org/0000-0002-3981-8227)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Sarah Baatout (ORCID: https://orcid.org/0000-0001-8110-751X)
- Angelique Van Ombergen (ORCID: https://orcid.org/0000-0002-3977-4279)
- Jan‐Bernd Stukenborg (ORCID: https://orcid.org/0000-0002-2839-1870)
- Alexander Choukèr (ORCID: https://orcid.org/0000-0002-0133-4104)
- Martina Heer (ORCID: https://orcid.org/0000-0001-5534-911X)
- Virginia E. Wotring
- Francesco Pagnini
- DM Bailey (ORCID: https://orcid.org/0000-0003-0498-7095)
- Hanns‐Christian Gunga
Institutions
- Università Cattolica del Sacro Cuore (IT)
- International Space University (FR)
- Uppsala University (SE)
- University of South Wales (GB)
- Karolinska University Hospital (SE)
- University of Bonn (DE)
- German Sport University Cologne (DE)
- University of Antwerp (BE)
- Inserm (FR)
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Baylor College of Medicine (US)
- Medical University of Graz (AT)
- European Space Agency (FR)
- Karolinska Institutet (SE)
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- LMU Klinikum (DE)
- Technische Universität Darmstadt (DE)
- Northumbria University (GB)
- Ghent University (BE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Erlangen (DE)
- European Astronaut Centre (DE)
- University of Applied Sciences Erfurt (DE)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- Amsterdam Neuroscience (NL)
- Belgian Nuclear Research Centre (BE)
- Federico II University Hospital (IT)
- Cognition, Action, and Sensorimotor Plasticity (FR)
- IU International University of Applied Sciences (DE)
- Amsterdam University Medical Centers (NL)
- University of Florence (IT)
- University of Naples Federico II (IT)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Université Jean Monnet (FR)
- University of Amsterdam (NL)
Publication Details
- Journal
- npj Microgravity
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1038/s41526-025-00537-1
- Citations
- 3
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- University of Pennsylvania
- Pennsylvania State University
- European Space Agency
- Bundesministerium für Bildung und Forschung
- Belgian Federal Science Policy Office
- Centre National d’Etudes Spatiales
- Institut Polaire Français Paul Emile Victor