Cytotoxic Cytochalasans from Sponge-Derived Aspergillus sp. SCSIO 41044
Two new cytochalasans (<b>1</b>-<b>2</b>), along with eight known ones (<b>3</b>-<b>10</b>) were isolated from sponge-derived <i>Aspergillus</i> sp. SCSIO 41044. The planar structures of <b>1</b>-<b>2</b> were elucidated through extensive spectroscopic analyses and their absolute configurations determined by modified Mosher's methods. Biological evaluation revealed that <b>5</b>, <b>7</b>, and <b>8</b> showed potent cytotoxicity against small cell lung cancers H446 and H1048, with IC<sub>50</sub> values ranging from 0.0441 to 1.61 μM.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0003-4748-2484)
- Ian Y. Wong (ORCID: https://orcid.org/0000-0002-9439-2548)
- Xuefeng Zhou (ORCID: https://orcid.org/0000-0001-9601-4869)
- Junfeng Wang (ORCID: https://orcid.org/0000-0001-6702-5366)
- Yonghong Liu (ORCID: https://orcid.org/0000-0001-8327-3108)
- Hong Wang (ORCID: https://orcid.org/0009-0005-5031-6593)
- Junjian Wang (ORCID: https://orcid.org/0000-0002-5328-2908)
- Xiaoyan Pang (ORCID: https://orcid.org/0009-0001-1972-0265)
- Qinlin Cao
Institutions
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
- South China Sea Institute Of Oceanology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Molecules
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3390/molecules30224483
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Institute of Oceanology, Chinese Academy of Sciences
- Basic and Applied Basic Research Foundation of Guangdong Province