FaceAge as a biomarker for prognosis and treatment stratification in a large-scale oncology cohort
Patients with more advanced cancers tend to have significantly older FaceAge compared with age, and extreme discordance between FaceAge and chronological age is a novel, independent predictor of survival and early mortality. These findings support further development of facial health assessments for clinical prognostication models and personalized treatment decision-making.
Authors
- Hugo J.W.L. Aerts (ORCID: https://orcid.org/0000-0002-2122-2003)
- Benjamin H. Kann (ORCID: https://orcid.org/0000-0002-4313-2754)
- Grace C. Lee (ORCID: https://orcid.org/0000-0001-5189-8373)
- John Cijiang He (ORCID: https://orcid.org/0000-0002-1502-2849)
- Dennis Bontempi (ORCID: https://orcid.org/0000-0003-0775-5679)
- Danielle S. Bitterman (ORCID: https://orcid.org/0000-0003-0345-2232)
- Dirk De Ruysscher (ORCID: https://orcid.org/0000-0001-9269-6567)
- Raymond H. Mak (ORCID: https://orcid.org/0000-0002-8754-0565)
- Osbert C. Zalay (ORCID: https://orcid.org/0000-0002-2967-4071)
- Paul J. Catalano (ORCID: https://orcid.org/0000-0002-1105-8852)
- Fridolin Haugg (ORCID: https://orcid.org/0000-0001-7205-6554)
- Suraj Pai (ORCID: https://orcid.org/0000-0001-8043-2230)
- Vasco Prudente (ORCID: https://orcid.org/0000-0003-0623-1259)
- Christian V. Guthier
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Queen's University (CA)
- Maastricht University (NL)
- Dana-Farber Cancer Institute (US)
- Maastro Clinic (NL)
- Dana-Farber Brigham Cancer Center (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- Mass General Brigham (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/jnci/djaf323
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00