Targeting Serotonin Pathways for Astronaut Safety and Performance

The HU mouse model showed plasma serotonin is elevated in HU mice, which corresponds to cortical and trabecular bone loss. These data suggest that elevated plasma serotonin may have a role in microgravity-induced bone loss. Specific serotonin receptor antagonists may be a safer countermeasure than currently used bisphosphonates to protect against astronaut bone loss. Casey TJ, Kubik AJ, Allen NG, Zilberman AH, Whitman BM, Hunt JC, Juran CM, French J, Blaber EA. Targeting serotonin pathways for astronaut safety and performance. Aerosp Med Hum Perform. 2025; 96(11):969-975.