Allogeneic haematopoietic cell transplantation promotes atherosclerosis in mice via CD8+ T cells

These data may provide a novel mechanistic underpinning for the clinically observed increased incidence of cardiovascular disease in long-term allo-HCT survivors. Moreover, we have identified CD8+ T cells as potential targets for mitigating GvHD-induced atherosclerosis.

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Publication Details

Journal
Cardiovascular Research
Published
2025-11-15
DOI
https://doi.org/10.1093/cvr/cvaf229
Citations
1
Primary Topic
Atherosclerosis and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
0.80
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article

Allogeneic haematopoietic cell transplantation promotes atherosclerosis in mice via CD8+ T cells

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1 citations
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Atherosclerosis and Cardiovascular Diseases
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article

Allogeneic haematopoietic cell transplantation promotes atherosclerosis in mice via CD8+ T cells

Haroon Shaikh, Heike M. Hermanns, Alma Zernecke, Maike Büttner‐Herold, Michael Kern, Louis Boon, Clément Cochain, Andreas Rosenwald, Maja Bundalo, Ivana Jorgacevic, Sarah Schäfer, Hendrik Bartolomaeus, Andreas Beilhack, Simone Reu‐Hofer, Elke Butt, Juan Gamboa Vargas, Antoine‐Emmanuel Saliba, Friederike Berberich‐Siebelt, Hasan Ali, Giuseppe Rizzo, Wolfgang Herr, Estibaliz Arellano Viera, Melanie Rösch
article en
1 citations

Abstract

These data may provide a novel mechanistic underpinning for the clinically observed increased incidence of cardiovascular disease in long-term allo-HCT survivors. Moreover, we have identified CD8+ T cells as potential targets for mitigating GvHD-induced atherosclerosis.

Cardiovascular ResearchVol. 121(17)
Inserm (FR), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Université Paris Cité (FR), University of Würzburg (DE), University Hospital Regensburg (DE), Sorbonne Paris Cité (FR), Comprehensive Cancer Center Mainfranken (DE), Institute of Agricultural and Food Biotechnology (PL), Helmholtz Institute for RNA-based Infection Research (DE), Universitätsklinikum Würzburg (DE), Paris Cardiovascular Research Center (FR)
Openalex Percentile: Top 21%
Atherosclerosis and Cardiovascular Diseases
0.80
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