Genetics of Thyroid Function: Relevance for Biology and Disease Management
Functional characterization of the associated genes and variants in GWAS is warranted as the majority are located in genes with a yet unknown role in thyroid hormone physiology. Integration of multi-omics data and optimalization of translational applications such as MR and PGS show potential to further unravel the underlying molecular mechanisms and pave the way for incorporation of genetics in personalized management of thyroid diseases.
Authors
- Marco Medici (ORCID: https://orcid.org/0000-0002-7271-7858)
- Rosalie Sterenborg (ORCID: https://orcid.org/0000-0003-4758-9185)
- W. Edward Visser (ORCID: https://orcid.org/0000-0002-5248-863X)
- Johannes W. A. Smit (ORCID: https://orcid.org/0000-0003-1052-9314)
- Aleksander Kuś (ORCID: https://orcid.org/0000-0001-5422-6900)
- Robin Patrick Peeters (ORCID: https://orcid.org/0000-0001-7732-9371)
- Alexander Teumer (ORCID: https://orcid.org/0000-0002-8309-094X)
Institutions
- Radboud University Nijmegen (NL)
- Medical University of Białystok (PL)
- Medical University of Warsaw (PL)
- Universitätsmedizin Greifswald (DE)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Universität Greifswald (DE)
- German Centre for Cardiovascular Research (DE)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1210/clinem/dgaf491
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00