The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac ageing
Our findings reveal that the Ets2 super-enhancer regulates Ets2 expression in cardiac endothelial cells, modulating heart ageing and EndoMT. Ets2's regulation of endothelial marker genes, especially TIE1, plays a pivotal role in mitigating EndoMT and preventing senescence in cardiac vascular endothelial cells, suggesting potential therapeutic targets for addressing cardiovascular ageing.
Authors
- Shasha Bian (ORCID: https://orcid.org/0000-0002-7095-0867)
- Jing Ma (ORCID: https://orcid.org/0000-0001-9074-8570)
- Yibin Hao (ORCID: https://orcid.org/0000-0002-3635-1668)
- Zhenglong Guo (ORCID: https://orcid.org/0000-0002-6251-3093)
- Wenke Yang (ORCID: https://orcid.org/0000-0002-1785-2184)
- Dawei Huo (ORCID: https://orcid.org/0000-0002-6144-7063)
- Lan Li (ORCID: https://orcid.org/0000-0002-6969-5256)
- Junwei Luo (ORCID: https://orcid.org/0000-0001-6841-9893)
- Shixiu Liao (ORCID: https://orcid.org/0000-0002-7173-7654)
- Yongchang Zhu (ORCID: https://orcid.org/0009-0004-8239-5866)
- Bingtao Hao (ORCID: https://orcid.org/0000-0003-1997-9338)
- Guanwei Fan
- Wei Xue (ORCID: https://orcid.org/0000-0003-3614-6194)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Shanghai Medical College of Fudan University (CN)
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Eye & ENT Hospital of Fudan University (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Henan Provincial People's Hospital (CN)
- Henan Provincial Eye Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1093/cvr/cvaf242
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81