Infantile Pyoderma Gangrenosum: A Rare and Challenging Case Presentation With an Updated Literature Review

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis in infancy, often misdiagnosed due to overlap with infectious and inflammatory conditions. We review existing literature on neonatal and infantile PG and present a case of a previously healthy 6-month-old male with rapidly progressive ulcerative lesions involving the face, scalp, extremities, and hard palate. Histopathology revealed a dense dermal neutrophilic infiltrate, and an extensive workup was unremarkable. The patient responded rapidly and completely to systemic corticosteroid monotherapy. Published cases similarly highlight idiopathic presentations and favorable outcomes with corticosteroids as first-line therapy. This case underscores the importance of recognizing PG in infants with rapidly progressive skin ulcers, even in the absence of systemic disease.