Insights on the practical application of the current treatment consensus in rhabdomyolysis management: a case report

Hemoadsorption has emerged as a promising adjunctive therapy in the management of various inflammatory and toxin-mediated conditions. Its role in context of rhabdomyolysis has generated increasing scientific and clinical interest. In response to the recent consensus statement by an international expert task force—published in BMC Nephrology in July 2024—regarding the use of hemoadsorption in rhabdomyolysis, we aim to contribute further to this evolving discourse. We report on a patient with severe rhabdomyolysis secondary to influenza B infection who suffered acute kidney injury (AKI) as a result. Alongside conservative treatment, we successfully implemented a combined regimen of CRRT and hemoadsorption, while using myoglobin levels up- and downstream of the adsorber as a tool for therapy monitoring. The patient subsequently recovered complete renal function and full body mobility. The case illustrates the practical implementation of hemoadsorption within a multimodal treatment strategy. In addition to demonstrating concordance with current consensus guidelines, we seek to critically discuss potential refinements in the therapeutic approach—particularly concerning monitoring strategies and the integration of extracorporeal modalities—to facilitate future clinical practice and research.

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Publication Details

Journal
BMC Nephrology
Published
2025-11-20
DOI
https://doi.org/10.1186/s12882-025-04590-6
Primary Topic
Muscle and Compartmental Disorders
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article
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article

Insights on the practical application of the current treatment consensus in rhabdomyolysis management: a case report

Daniel A. Reuter, Thiago Reis, Steffen R Mitzner, Gonzalo Ramírez‐Guerrero et al.
BMC Nephrology
Muscle and Compartmental Disorders
article

Insights on the practical application of the current treatment consensus in rhabdomyolysis management: a case report

Daniel A. Reuter, Thiago Reis, Steffen R Mitzner, Gonzalo Ramírez‐Guerrero, Sebastian Koball, Jens‐Christian Schewe, Matteo Marcello, Faeq Husain‐Syed, Gerd Klinkmann, Claudio Ronco, T. E. GIER
article en

Abstract

Hemoadsorption has emerged as a promising adjunctive therapy in the management of various inflammatory and toxin-mediated conditions. Its role in context of rhabdomyolysis has generated increasing scientific and clinical interest. In response to the recent consensus statement by an international expert task force—published in BMC Nephrology in July 2024—regarding the use of hemoadsorption in rhabdomyolysis, we aim to contribute further to this evolving discourse. We report on a patient with severe rhabdomyolysis secondary to influenza B infection who suffered acute kidney injury (AKI) as a result. Alongside conservative treatment, we successfully implemented a combined regimen of CRRT and hemoadsorption, while using myoglobin levels up- and downstream of the adsorber as a tool for therapy monitoring. The patient subsequently recovered complete renal function and full body mobility. The case illustrates the practical implementation of hemoadsorption within a multimodal treatment strategy. In addition to demonstrating concordance with current consensus guidelines, we seek to critically discuss potential refinements in the therapeutic approach—particularly concerning monitoring strategies and the integration of extracorporeal modalities—to facilitate future clinical practice and research.

BMC NephrologyVol. 26(1)
Universidade de São Paulo (BR), Centro Paulista de Investigação Clinica (BR), Universities of Giessen and Marburg Lung Center (DE), Fraunhofer Institute for Cell Therapy and Immunology (DE), Ospedale San Bortolo (IT), International Renal Research Institute of Vicenza (IT), Hospital Las Higueras (CL), University of Rostock (DE)
Openalex Percentile: Top 46%
Muscle and Compartmental Disorders
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