Gestational diabetes alters prefrontal neurochemistry and disrupts maternal behaviors: Role of Fibrillin-1, serotonin, and TNF-α in rats
These results demonstrate that GDM significantly dysregulates prefrontal cortex neurochemistry (increasing TNF-α and FBN1 mRNA while decreasing serotonin) and profoundly weakens maternal behavior, affecting its endurance, speed of integration, and emotional components in rats.
Authors
- Samira Khayat (ORCID: https://orcid.org/0000-0001-7514-7128)
- Hamed Fanaei (ORCID: https://orcid.org/0000-0002-1345-2052)
- Abdolvahed Safarzaei
Institutions
- Zahedan University of Medical Sciences (IR)
Publication Details
- Journal
- Metabolism Open
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.metop.2025.100422
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00