Fibrolamellar carcinoma: The role of imaging in diagnosis and management

Liver cancer is one of the most prevalent malignancies worldwide, with hepatocellular carcinoma accounting for approximately 80% of primary liver tumors. Fibrolamellar carcinoma is a rare variant that predominantly affects young individuals without underlying liver disease. Due to its nonspecific clinical presentation and the absence of typical risk factors, diagnosis is often delayed until advanced stages. Correlating imaging findings with clinical and histopathological data is essential for accurate diagnosis and effective treatment, highlighting the need for a multidisciplinary approach to managing these rare neoplasms. We present the case of a 15-year-old patient diagnosed with fibrolamellar carcinoma, emphasizing the critical role of imaging in its identification and the importance of an aggressive surgical approach to optimizing long-term outcomes.

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Journal
Radiology Case Reports
Published
2025-11-20
DOI
https://doi.org/10.1016/j.radcr.2025.10.013
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
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article

Fibrolamellar carcinoma: The role of imaging in diagnosis and management

Andrés Hernando Tascón-Barona, Ana Clarete, Diana Melo-Alvear
Radiology Case Reports
Hepatocellular Carcinoma Treatment and Prognosis
article

Fibrolamellar carcinoma: The role of imaging in diagnosis and management

Andrés Hernando Tascón-Barona, Ana Clarete, Diana Melo-Alvear
article en

Abstract

Liver cancer is one of the most prevalent malignancies worldwide, with hepatocellular carcinoma accounting for approximately 80% of primary liver tumors. Fibrolamellar carcinoma is a rare variant that predominantly affects young individuals without underlying liver disease. Due to its nonspecific clinical presentation and the absence of typical risk factors, diagnosis is often delayed until advanced stages. Correlating imaging findings with clinical and histopathological data is essential for accurate diagnosis and effective treatment, highlighting the need for a multidisciplinary approach to managing these rare neoplasms. We present the case of a 15-year-old patient diagnosed with fibrolamellar carcinoma, emphasizing the critical role of imaging in its identification and the importance of an aggressive surgical approach to optimizing long-term outcomes.

Radiology Case ReportsVol. 21(2)
Fundación Valle del Lili (CO)
Openalex Percentile: Top 54%
Hepatocellular Carcinoma Treatment and Prognosis
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