Optic Disc Flavoprotein Fluorescence Imaging as a Novel Method to Quantify Disease Burden in Optic Disc Drusen
Disc FPF is an objective imaging technique to quantify disease burden in ODD, reflecting a combination of drusen autofluorescence signal and metabolic stress from axonopathy. Disc FPF is correlated with structural and functional changes and has high predictive power of visual field loss in ODD, supporting its use as an outcome measure in prospective natural history and treatment studies in ODD.
Authors
- Ping Zhu (ORCID: https://orcid.org/0000-0002-4276-9593)
- Jamie Zhang
- Shannon Beres (ORCID: https://orcid.org/0000-0002-9524-1258)
- Yaping Joyce Liao (ORCID: https://orcid.org/0000-0001-7958-291X)
- Collin Rich
- Sangeethabalasri Pugazhendhi
- Heather E. Moss (ORCID: https://orcid.org/0000-0003-4373-447X)
- Miaomiao Yu (ORCID: https://orcid.org/0000-0003-4979-6911)
- Rishita Rama Pujari (ORCID: https://orcid.org/0009-0002-0096-6246)
- Lorraine Almeda
Institutions
- Michigan Medicine (US)
- Stanford Medicine (US)
- Ann Arbor Center for Independent Living (US)
- Stanford University (US)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ajo.2025.11.018
- Primary Topic
- Cerebral Venous Sinus Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00