Integrating [11C]methylreboxetine PET and MRI to map in vivo norepinephrine transporter distribution: A proof-of-concept study of noradrenergic vulnerability in neurodegeneration
This study integrates [<sup>11</sup>C]MRB PET and MRI to examine noradrenergic integrity in Alzheimer's and Parkinson's disease. Results demonstrate strong PET-MRI convergence in the locus coeruleus, but not in projection regions, highlighting the locus coeruleus as a sensitive biomarker target and supporting multimodal imaging approaches for early detection of neurodegenerative vulnerability.
Authors
- Debby Van Dam (ORCID: https://orcid.org/0000-0003-4739-6076)
- Rudi Dierckx
- Bruno Lima Giacobbo (ORCID: https://orcid.org/0000-0002-2507-7675)
- Jaime D. Mondragón (ORCID: https://orcid.org/0000-0001-6416-4942)
- Sofia Marcolini (ORCID: https://orcid.org/0000-0002-1856-9348)
- M. De Tollenaere
- Peter P. De Deyn
- P. H. Elsinga
Institutions
- University Medical Center Groningen (NL)
- University of Antwerp (BE)
- University of Groningen (NL)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.nucmedbio.2025.109581
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91