Reconfigurable Acoustic Printing for Conformal and Minimally Invasive Repair
Abstract Minimally invasive tissue repair is essential in reconstructive and orthopedic surgery to reduce infection and scarring. However, current 3D/4D printing and stimulus‐responsive materials remain constrained by the need for larger incisions and limited penetration of light and heat stimuli. Here, reconfigurable acoustic printing (RAP), a platform that harnesses focused acoustic waves to enable remote printing, healing, and shape reconfiguration with centimeter‐scale penetration depths through biological tissue, is introduced. By using a specially formulated bioacoustic ink, RAP achieves high‐resolution transcutaneous solidification and reconfigurable shape morphing, inspired by origami principles. Acoustic stimulation further induces controlled material softening, allowing precise structural repair and localized reconfiguration. In live animal models, RAP successfully demonstrates in vivo transcutaneous printing and conformable defect repair. This strategy establishes a versatile and powerful approach for minimally invasive biomedical applications, spanning tissue engineering, implant repair, and aesthetic medicine.
Authors
- Zhengyi Mao (ORCID: https://orcid.org/0000-0001-5947-7282)
- Amr Osman (ORCID: https://orcid.org/0000-0003-3675-1992)
- Daniel Ahmed (ORCID: https://orcid.org/0000-0002-0224-5293)
- Hanyang Yu (ORCID: https://orcid.org/0000-0003-1257-1735)
- Yunhu He (ORCID: https://orcid.org/0000-0002-8202-5492)
- Yuanchao Liu (ORCID: https://orcid.org/0000-0001-7699-488X)
- Yingqiang Wang (ORCID: https://orcid.org/0000-0001-9876-4225)
- Mulin Miao (ORCID: https://orcid.org/0000-0003-0975-8486)
- Zhen Li (ORCID: https://orcid.org/0000-0002-2335-7243)
- Jian Lü (ORCID: https://orcid.org/0000-0001-5362-0316)
- Yu‐Long Wang (ORCID: https://orcid.org/0000-0002-6508-0051)
- Zhen Yu (ORCID: https://orcid.org/0000-0001-5210-2672)
- Yuhan Chen (ORCID: https://orcid.org/0000-0001-9796-0291)
- Ying Li (ORCID: https://orcid.org/0000-0001-9834-7376)
- Xuliang Chen (ORCID: https://orcid.org/0000-0003-1081-2822)
- Wanying Wang (ORCID: https://orcid.org/0000-0003-0765-8430)
- Chaochao Sun (ORCID: https://orcid.org/0009-0003-3635-5428)
Institutions
- City University of Hong Kong (HK)
- Shanghai Jiao Tong University (CN)
- Southern University of Science and Technology (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Robotic Technology (United States) (US)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/adfm.202525723
- Primary Topic
- Advanced Materials and Mechanics
- Type
- article
- Field-Weighted Citation Impact
- 0.00