Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment
Effects of seven antihypertensives of Losartan Kalicum(LK), Atenolol(ATEN), Nifedipine(NF), Hydrochlorothiazide(HCTZ), Valsartan(VLA), Furosemide(FUR) and Captopril(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank's solution). LK, NF and HCTZ with the concentrations of 0.5, 1.0 and 0.5 g/L can remarkably enhance the degradation resistance of AZ31 alloy by 63.1, 69.4 and 70.5%, respectively. The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants.
Authors
- Guangling Wei (ORCID: https://orcid.org/0000-0002-1038-7734)
- Kui Wang (ORCID: https://orcid.org/0000-0001-9610-8689)
- Min Fan (ORCID: https://orcid.org/0000-0002-7927-3954)
- Gang Xiao (ORCID: https://orcid.org/0000-0002-0806-2156)
- Yazhao Shen
- Haonan Li (ORCID: https://orcid.org/0009-0002-7803-4748)
- Haiyan Yang (ORCID: https://orcid.org/0000-0002-9583-8847)
- Haiyan Jiang (ORCID: https://orcid.org/0000-0001-5580-2957)
- X.D. Cai (ORCID: https://orcid.org/0009-0000-0598-8386)
Institutions
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Inner Mongolia University (CN)
- Ruijin Hospital (CN)
- Inner Mongolia Electric Power Survey & Design Institute (China) (CN)
- Baotou Research Institute of Rare Earths (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1038/s41598-025-24906-8
- Primary Topic
- Magnesium Alloys: Properties and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia
- Shanghai Jiao Tong University
- National Key Research and Development Program of China