Primary Aldosteronism: Small Molecule Antagonists of Mutant KCNJ5 Potassium Channels
C81 shows potential as a small molecule antagonist to specifically target pathological aldosterone secretion in familial hyperaldosteronism type III or <i>KCNJ5</i>-mutated aldosterone-producing adenomas. These findings suggest new avenues for genotype-based primary aldosteronism diagnostics and targeted treatments, contributing to personalized patient care.
Authors
- Martín Reincke (ORCID: https://orcid.org/0000-0002-9817-9875)
- Martina Tetti
- Mirko Peitzsch (ORCID: https://orcid.org/0000-0002-2472-675X)
- Tracy Ann Williams (ORCID: https://orcid.org/0000-0002-2388-6444)
- Sanas Mir-Bashiri (ORCID: https://orcid.org/0009-0008-9051-1424)
- Graeme Eisenhofer (ORCID: https://orcid.org/0000-0002-8601-9903)
- Dennis Fröbel (ORCID: https://orcid.org/0009-0002-2463-0819)
- Nicole Bechmann (ORCID: https://orcid.org/0000-0002-6932-333X)
- Yuhong Yang (ORCID: https://orcid.org/0000-0002-3639-9055)
- Yingxian Pang
- D Reiss
- Jonas Bibus
Institutions
- LMU Klinikum (DE)
- Department of Medical Sciences (BY)
- University Hospital Carl Gustav Carus (DE)
- Ludwig-Maximilians-Universität München (DE)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25360
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00