The effects of Lithium on Beta-amyloid deposition and tau phosphorylation: A systematic review
Lithium potentially reduces intracerebral amyloid deposition and tau phosphorylation in AD animal models and may reverse associated cognitive deficits. Further research should seek to replicate similar findings in larger samples and explore lithium's optimal dosage range in promoting intracerebral amyloid clearance.
Authors
- Jingwen Ai (ORCID: https://orcid.org/0000-0002-5152-1557)
- Gia Han Le (ORCID: https://orcid.org/0000-0001-6457-0086)
- Joshua D. Rosenblat (ORCID: https://orcid.org/0000-0002-4773-2191)
- Melanie C. Zhang (ORCID: https://orcid.org/0009-0002-0638-8184)
- Heidi Ka Ying Lo (ORCID: https://orcid.org/0000-0003-2551-5230)
- Kayla M. Teopiz (ORCID: https://orcid.org/0000-0001-8429-6563)
- Maj Vinberg (ORCID: https://orcid.org/0000-0002-5982-1335)
- Elizaveta Kirichek
- Kelei Xiao
- Xiangyu Zhang (ORCID: https://orcid.org/0009-0003-1756-3280)
- Jinchun Xing (ORCID: https://orcid.org/0000-0002-1651-5223)
- Hisham Sayed
- Sabrina Wong (ORCID: https://orcid.org/0009-0002-0928-3433)
- Kyle Valentino
- Roger S. McIntyre
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Brain and Cognition Discovery Foundation (CA)
- Capital Region of Denmark (DK)
- University of Hong Kong (HK)
- McMaster University (CA)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jad.2025.120721
- Citations
- 1
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47