Longitudinal impact of CYP2D6 and CYP2C19 metabolizer status on antidepressant response: The role of Pharmacogenetic mismatch
While categorical response and remission rates did not differ between groups and numerically favored the mismatch group, side-effect burden was modestly higher with mismatch; continuous trajectories nevertheless showed a small but consistent disadvantage associated with mismatch.
Authors
- Gabriele Nibbio (ORCID: https://orcid.org/0000-0001-7570-2195)
- Sergio Barlati (ORCID: https://orcid.org/0000-0002-1784-3915)
- Raffaele Ferri (ORCID: https://orcid.org/0000-0001-6937-3065)
- Giulia Perusi
- Massimo Gennarelli (ORCID: https://orcid.org/0000-0003-4192-945X)
- Lisa Buson (ORCID: https://orcid.org/0000-0003-1910-4232)
- Antonio Vita (ORCID: https://orcid.org/0000-0002-3621-6394)
- Stefano Bignotti (ORCID: https://orcid.org/0000-0002-7840-9637)
- G.B. Tura (ORCID: https://orcid.org/0000-0002-4689-4746)
- Alessandro Serretti (ORCID: https://orcid.org/0000-0003-4363-3759)
- Valentina Menesello (ORCID: https://orcid.org/0000-0002-8414-2203)
- Rosana Carvalho Silva (ORCID: https://orcid.org/0000-0001-7984-5628)
- Alessandra Minelli (ORCID: https://orcid.org/0000-0002-9463-7808)
- Chiara Fabbri
- Anna Magistrali
Institutions
- Oasi Maria SS (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Brescia (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jad.2025.120724
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00