Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1/Nrf2/NF-κB pathway
This study demonstrated that in the R28 cell injury model induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation, SCU can promote the proliferation of R28 cells and reduce the expression of apoptotic factors through the antioxidant stress effect mediated by the Keap1/Nrf2/Nf-κB signaling pathway. This finding provides a potentially effective candidate compound and a mechanistic approach for the drug treatment of glaucoma optic nerve protection.
Authors
- Qinghua Peng (ORCID: https://orcid.org/0000-0002-9378-1330)
- Yijing Yang (ORCID: https://orcid.org/0000-0003-4197-2570)
- Jun Peng (ORCID: https://orcid.org/0000-0002-0458-1733)
- Jiangwei Li (ORCID: https://orcid.org/0000-0001-8916-0294)
- Yu Huang (ORCID: https://orcid.org/0009-0003-4802-3017)
- Xin Xia
- Hongmei Cui
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Fuzhou Second Hospital (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.tice.2025.103234
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00