Elevated Alkaline Phosphatase Is Associated With Increased Rates of Pseudoarthrosis and Perioperative Complications Following Lumbar Fusion Surgery
Elevated ALP is strongly associated with increased odds of pseudoarthrosis, readmission, and ROR after lumbar spinal arthrodesis and retained a strong association with pseudoarthrosis and ROR after ASA stratification. Conversely, low ALP levels may offer a protective effect against pseudoarthrosis, though not statistically significant. These results may inform surgeons of risks associated with elevated ALP levels before lumbar spine fusion surgery and highlight the importance of comprehensive medical optimization.
Authors
- Jason Liang (ORCID: https://orcid.org/0000-0001-8648-7785)
- Abhinav K. Sharma (ORCID: https://orcid.org/0000-0003-4932-6629)
- Michael E. Steinhaus (ORCID: https://orcid.org/0000-0002-0348-0754)
- Manu Mehta (ORCID: https://orcid.org/0009-0004-8445-0806)
- Hao‐Hua Wu (ORCID: https://orcid.org/0000-0003-1048-3889)
- Nitin Bhatia (ORCID: https://orcid.org/0000-0001-7905-3305)
- Paramveer Birring (ORCID: https://orcid.org/0000-0001-8391-8578)
- Frederik Heath
- Zorica Buser (ORCID: https://orcid.org/0000-0002-5680-0643)
- Nischal Acharya (ORCID: https://orcid.org/0000-0002-0349-2034)
- Sohaib Hashmi (ORCID: https://orcid.org/0000-0002-5256-3820)
- Yu-Po Lee (ORCID: https://orcid.org/0000-0002-2365-2373)
- Don Young Park (ORCID: https://orcid.org/0000-0001-9922-3316)
- Nicole Goldenhersh
Institutions
- University of Massachusetts Chan Medical School (US)
- University of California, Irvine (US)
- The Spine Institute (US)
- Neurological Surgery (US)
- New York University (US)
Publication Details
- Journal
- Clinical Spine Surgery A Spine Publication
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1097/bsd.0000000000001902
- Primary Topic
- Alkaline Phosphatase Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00