Traditional herbal medicine Ga-Mi Gongjindan improves muscarinic cholinergic dysfunction through regulation of BDNF/CREB signaling pathway using a scopolamine-induced cognitive impairment of mouse model
GJD exerted significant neuroprotective effects in a scopolamine-induced model of cognitive dysfunction, potentially via modulation of cholinergic and BDNF/CREB signaling pathways. These findings provide a scientific rationale for the traditional use of GJD in cognitive disorders and support its further development as a candidate for treating neurodegenerative diseases such as AD.
Authors
- Joon‐Sang Park (ORCID: https://orcid.org/0000-0002-6459-1060)
- Ho-ryong Yoo (ORCID: https://orcid.org/0000-0001-6152-7488)
- Jong-Suk Lee (ORCID: https://orcid.org/0000-0002-1951-0516)
- Hyeong-Geug Kim (ORCID: https://orcid.org/0000-0002-6489-5873)
- Jae-Hong Joo
Institutions
- Korea University Medical Center (KR)
- Korea Institute of Oriental Medicine (KR)
- Bio-Medical Science (South Korea) (KR)
- QPS (United States) (US)
- Daejeon Oriental Hospital (KR)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111644
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00