Endothelial CD40L serves as a pro-atherogenic adhesion receptor in the inflamed vasculature
In this functional validation study, we demonstrate that endothelial cell-expressed CD40L serves as an adhesion molecule in different models of acute inflammation in the aortic, peritoneal, mesenteric, and coronary vasculature. CD40L may therefore represent a promising therapeutic target at the interface of adaptive immunity and myeloid inflammation.
Authors
- Timothy Mwinyella (ORCID: https://orcid.org/0000-0002-5977-3513)
- Tijani Abogunloko (ORCID: https://orcid.org/0000-0001-7605-5401)
- Abed Al Hadi El Rabih
- Norbert Gerdes (ORCID: https://orcid.org/0000-0002-4546-7208)
- Timoteo Marchini (ORCID: https://orcid.org/0000-0002-5758-4348)
- Andreas Zirlik (ORCID: https://orcid.org/0000-0001-6290-3297)
- Sophie Hansen
- Patrick M. Siegel (ORCID: https://orcid.org/0000-0002-6976-8961)
- Mark Colin Gissler (ORCID: https://orcid.org/0000-0002-5249-0174)
- Dennis Wolf (ORCID: https://orcid.org/0000-0003-1525-4348)
- Philipp Scherrer (ORCID: https://orcid.org/0000-0003-1753-4757)
- Ingo Hilgendorf (ORCID: https://orcid.org/0000-0002-0024-1643)
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Natalie Hoppe
- Lucía Sol Mitre (ORCID: https://orcid.org/0000-0001-7796-675X)
- Esther Lutgens (ORCID: https://orcid.org/0000-0002-2609-5744)
- Daniela Stallmann
- Hauke Horstmann (ORCID: https://orcid.org/0000-0002-9971-1800)
- Lisa Spiga
- Florian Willecke (ORCID: https://orcid.org/0000-0002-7729-8808)
- Juan José Domínguez
- Jan Pennig
- Xiaowei Li (ORCID: https://orcid.org/0000-0002-0718-1938)
- Christian Weber (ORCID: https://orcid.org/0000-0003-4610-8714)
- Guido Pisani
- Nathaly Anto Michel
Institutions
- University of Freiburg (DE)
- Bielefeld University (DE)
- Medical University of Graz (AT)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- University Medical Center Freiburg (DE)
- Düsseldorf University Hospital (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120517
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Albert-Ludwigs-Universität Freiburg
- Else Kröner-Fresenius-Stiftung
- Deutsche Herzstiftung
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
- Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg