Effects of esketamine combined with dexmedetomidine on oxidative stress and lung function during one-lung ventilation in patients with mild to moderate COPD undergoing thoracoscopic surgery
Low-dose esketamine combined with dexmedetomidine, administered before anesthesia induction, improved intraoperative pulmonary mechanics and oxygenation, and attenuated inflammation and oxidative stress in patients with mild-to-moderate COPD undergoing VATS. The combination also helped maintain hemodynamic stability and reduced postoperative pain, contributing to enhanced perioperative recovery.
Authors
- Wan-Ping Hong
- Shuo Huang (ORCID: https://orcid.org/0000-0001-9495-4339)
- Ang Liu (ORCID: https://orcid.org/0009-0000-5558-0856)
- Xiaoting Xu (ORCID: https://orcid.org/0000-0002-8654-2972)
- Yu Mao (ORCID: https://orcid.org/0000-0002-5754-3773)
- Ying Liu (ORCID: https://orcid.org/0000-0002-6540-0473)
- Xiaoqi Zhang (ORCID: https://orcid.org/0000-0003-0707-0928)
- Yifeng Hong (ORCID: https://orcid.org/0009-0008-6500-4674)
- Zhi-yuan Chen (ORCID: https://orcid.org/0000-0002-9802-4208)
- Wen-Xi Xie
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Heze Municipal Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.intimp.2025.115860
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00