Cumulative IVF Pregnancy Rates After Transfer of Day 5 Fresh and Frozen Embryos in Agonist Cycles

Objectives The primary aim of the study was to review the data of the outcome of the patients undergoing in vitro fertilisation-embryo transfer (IVF-ET) cycles with the conventional agonist downregulated protocol. A retrospective study evaluating the overall efficacy of an IVF Program that included conventional agonist stimulation cycles with an HCG trigger, followed by fresh and/or blastocyst transfers in subsequent Frozen-Thawed Cycles was conducted. Material and Methods Retrospective patient records of 154 women who received an IVF treatment at Kamlesh Tandon Test Tube Baby Centre, Agra, between July 2022 to April 2024 were analysed. The patients were divided into two groups: Group 1, those who underwent fresh embryo transfer (N = 122), and Group 2, those who had frozen embryo transfer (FET) (N = 32). All the patients who underwent IVF cycles during the above period were included in the study. All patients underwent controlled ovarian stimulation followed by oocyte retrieval and fresh embryo transfers. Patients with high serum oestradiol levels and over 15 oocytes were deferred for a fresh embryo transfer. A freeze-all policy was followed by a subsequent freeze-thawed embryo transfer cycle. Results 63 patients in the fresh transfer group (51.63%) and 21 (65.62%) in FET had positive β-HCG. The implantation rates (43.75%) and live birth rates (56.25%) were higher in the FET group than in the fresh embryo transfer group (25.78% and 45.08%), respectively. Conclusion Patients who had IVF by FET showed a higher pregnancy rate and more successful fertility and pregnancy outcomes compared to patients who underwent IVF by fresh embryo transfer. The study holds its limitation first by a small sample size, and secondly, it would be an ideal scenario if a similar cohort with an antagonist stimulation protocol were compared with the rest of the parameters being kept the same.