Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review
This systematic scoping review provides a comprehensive summary of the evidence of the risks and benefits of analgesics and sedatives in ventilated premature infants. Although morphine is the most extensively studied and used drug, its analgesic effect has been less consistently reported than that of fentanyl. Sedation has rarely been assessed and dexmedetomidine seems a promising sedative adjunct as midazolam use is not supported by evidence.
Authors
- Fiona Moultrie (ORCID: https://orcid.org/0000-0002-1431-791X)
- Xavier Durrmeyer (ORCID: https://orcid.org/0000-0002-6303-7252)
- Luke Baxter (ORCID: https://orcid.org/0000-0001-9548-7162)
- Samyuktha Iyer (ORCID: https://orcid.org/0009-0008-8667-8256)
- Manon Tauzin (ORCID: https://orcid.org/0000-0003-0547-4566)
- Rebeccah Slater (ORCID: https://orcid.org/0000-0003-1595-4846)
- Aomesh Bhatt (ORCID: https://orcid.org/0000-0001-6206-0576)
- Gerbrich E. van den Bosch (ORCID: https://orcid.org/0000-0003-1862-1334)
- Sinno H. P. Simons (ORCID: https://orcid.org/0000-0001-5219-5696)
- María M. Cobo (ORCID: https://orcid.org/0000-0002-3961-1568)
- Emma Olsson
- Jean Michel Roué
Institutions
- Université Paris-Est Créteil (FR)
- Örebro University (SE)
- University of Oxford (GB)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Hôpital Intercommunal de Créteil (FR)
- Institut Mondor de Recherche Biomédicale (FR)
- Universidad San Francisco de Quito (EC)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1038/s41390-025-04441-y
- Citations
- 2
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 6.99