RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression
The results demonstrate that PTBP1 mediates HSV-1 infection of epithelial cells through splicing regulation of HS3ST3A1/HS3ST3B1. These studies provide a new area for novel therapeutic strategies through splicing regulation.
Authors
- Erguang Li (ORCID: https://orcid.org/0000-0002-3065-1336)
- Ameena Tur Rasool (ORCID: https://orcid.org/0009-0006-7381-0874)
- Peng Cao (ORCID: https://orcid.org/0000-0002-2044-3074)
- Renjie Luo
- Mengyu Zhang (ORCID: https://orcid.org/0000-0001-9375-6664)
- Ruilin Wang (ORCID: https://orcid.org/0009-0006-5395-8265)
- Xiangdong Liu (ORCID: https://orcid.org/0000-0001-6208-4818)
- Jie Yang (ORCID: https://orcid.org/0000-0003-0706-7358)
- Weikang Sun
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Hunan University of Arts and Science (CN)
- Southeast University (BD)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1186/s13578-025-01495-7
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China