Structural and Spectroscopic Study of Benzoperimidines Derived from 1-Aminoanthraquinone and Their Application to Bioimaging
In this research, we studied the synthesis and characterization of a novel amidine derivative of benzoperimidine derived from 1-aminoanthraquinone, focusing on its emission properties and potential applications in confocal laser scanning microscopy. The synthesized compound exhibited pronounced solvatochromic behavior in various solvents. Spectroscopic analysis, including <sup>1</sup>H-, <sup>13</sup>C-, and mass spectrometry, confirmed the chemical structure. The structure of three compounds was also determined using X-ray diffraction analysis; this study revealed the structural features of these substances in the solid state. The compound's antimicrobial activity was evaluated using the agar diffusion method with the bacterium <i>Bacillus subtilis</i> subsp. <i>Spizizenii</i>. Furthermore, the study introduces a dye designed for imaging of the parasitic flatworm <i>Opisthorchis felineus</i>, demonstrating its potential in visualizing biological specimens.
Authors
- Ilze Rubeniņa (ORCID: https://orcid.org/0000-0001-9515-9791)
- Lyudmila Lider (ORCID: https://orcid.org/0000-0001-5842-0751)
- Armands Maļeckis (ORCID: https://orcid.org/0000-0002-6790-6320)
- Aleksandrs Pučkins (ORCID: https://orcid.org/0000-0001-9006-0493)
- Muza Kirjušina (ORCID: https://orcid.org/0000-0002-6067-6200)
- Inta Umbraško (ORCID: https://orcid.org/0009-0009-5792-9033)
- Sergey Belyakov (ORCID: https://orcid.org/0000-0002-9078-3920)
- Vladimir S. Kiyan (ORCID: https://orcid.org/0000-0001-9787-9151)
- Sanita Kecko (ORCID: https://orcid.org/0000-0001-8612-4116)
- Veronika Pavlova
- Aija Brakovska (ORCID: https://orcid.org/0000-0003-2716-6839)
- Elena M. Kirilova (ORCID: https://orcid.org/0000-0002-9577-5612)
- Ligita Mežaraupe (ORCID: https://orcid.org/0009-0001-2560-8536)
Institutions
- Daugavpils University (LV)
- National Center for Biotechnology (KZ)
- Latvijas Organiskās Sintēzes Institūts (LV)
- S.Seifullin Kazakh Agro Technical University (KZ)
Publication Details
- Journal
- Molecules
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3390/molecules30224472
- Primary Topic
- Morinda citrifolia extract uses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Latvijas Zinātnes Padome