Subtype-specific roles of nigrostriatal dopaminergic neurons in motor and associative learning
Both <i>Calb1</i> <sup>+</sup> and <i>Aldh1a1</i> <sup>+</sup> nigrostriatal DANs are key regulators of movement and motor learning, with <i>Calb1</i> <sup>+</sup> neurons additionally modulating reward-based associative learning. These findings highlight the functional heterogeneity of nigrostriatal DAN subtypes and identify potential therapeutic targets for addressing motor and non-motor deficits in Parkinson's disease.
Authors
- Weidong Le (ORCID: https://orcid.org/0000-0001-7459-2705)
- Lupeng Wang (ORCID: https://orcid.org/0000-0002-3706-4564)
- Huaibin Cai (ORCID: https://orcid.org/0000-0002-8596-6108)
- Ahsan Habib (ORCID: https://orcid.org/0000-0001-9496-3681)
- Lixin Sun (ORCID: https://orcid.org/0000-0001-8203-0841)
- Lulu Tian (ORCID: https://orcid.org/0000-0001-5820-0337)
- Lisa Chang (ORCID: https://orcid.org/0009-0008-8879-9246)
- Victor M. Martinez Smith
- Disa Basu
- Gavin Riccobono
Institutions
- National Institutes of Health (US)
- Dalian Medical University (CN)
- National Institute on Aging (US)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Ageing and Neurodegenerative Diseases
- Published
- 2025-11-19
- DOI
- https://doi.org/10.20517/and.2025.26
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Mental Health