Serum metabolites link immune-microbiota interaction in children and young adults from Russian Karelia and Finnish Karelia with contrasting lifestyle and environment
Multi-omics integration revealed a more coordinated and responsive immune-metabolic network in RUS youth, potentially shaped by environmental exposures typical of their living context. In contrast, the FIN cohort exhibited metabolic patterns more closely linked to inflammatory gene expression.
Authors
- Hanna Sinkko (ORCID: https://orcid.org/0000-0002-4003-0429)
- Harri Alenius (ORCID: https://orcid.org/0000-0003-0106-8923)
- Tari Haahtela (ORCID: https://orcid.org/0000-0003-4757-2156)
- Anni I. Nieminen (ORCID: https://orcid.org/0000-0001-8999-6040)
- Mika J. Mäkelä (ORCID: https://orcid.org/0000-0002-2933-3111)
- Laura Paalanen (ORCID: https://orcid.org/0000-0003-2738-2654)
- Piia Karisola (ORCID: https://orcid.org/0000-0003-0635-2704)
- Erkki Vartiainen (ORCID: https://orcid.org/0000-0001-7498-4389)
- Ying Yang (ORCID: https://orcid.org/0000-0002-8059-1896)
- Tiina Laatikainen
- Nanna Fyhrquist
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Karolinska Institutet (SE)
- Humak University of Applied Sciences (FI)
- Finnish Institute for Health and Welfare (FI)
- Wihuri Research Institute (FI)
Publication Details
- Journal
- Environment International
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.envint.2025.109911
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00