Loss of Intestinal Endosome-associated Protein Sorting Nexin 27 Disrupts Epithelial Barrier and Promotes Inflammation
Overall, deletion of intestinal epithelial SNX27 weakens barrier functions and promotes inflammation. Our results indicate a novel role of SNX27 in regulating intestinal physiology and protecting against intestinal disorders. Thus, understanding the mechanisms of SNX27 downregulation in IBD will provide insights into new prevention and targets against chronic inflammation.
Authors
- Jun Sun (ORCID: https://orcid.org/0000-0001-7465-3133)
- Yinglin Xia (ORCID: https://orcid.org/0000-0001-6857-7437)
- Yongguo Zhang (ORCID: https://orcid.org/0000-0002-8299-0233)
- Yu An (ORCID: https://orcid.org/0000-0002-9678-3382)
- Shreya Deb (ORCID: https://orcid.org/0000-0002-4937-6979)
Institutions
- University of Illinois Chicago (US)
- University of Chicago Medical Center (US)
- Jesse Brown VA Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101682
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84