Loss of NKCC1 Activates the NLRP3 Inflammasome in Intestinal Epithelia
NKCC1 functions as a negative regulator of NLRP3 inflammasome activation and this may explain why patients of loss-of-function mutations in NKCC1 are susceptible to inflammatory diseases.
Authors
- Xenia Davis
- Rainelli Koumangoye (ORCID: https://orcid.org/0000-0002-5963-8987)
- Julia K. Bohannon (ORCID: https://orcid.org/0000-0003-0460-9377)
- Mohammed Zubaerul Ferdaus (ORCID: https://orcid.org/0000-0002-4860-5506)
- Eric J. Delpire (ORCID: https://orcid.org/0000-0002-3702-1599)
Institutions
- Vanderbilt University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101681
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81