Neuromedin B identified as a therapeutic target for atopic dermatitis: evidence from Mendelian randomization and PCR validation
Integrative MR and PCR validation across Icelandic, Finnish and Chinese samples nominates NMB as a candidate AD target. These preliminary, multi-ancestry signals now require replication in large, population-matched cohorts before any therapeutic translation.
Authors
- Lingling Zhang (ORCID: https://orcid.org/0009-0008-0358-9777)
- Jiang Ji (ORCID: https://orcid.org/0000-0002-8888-3690)
- Changwen Ke (ORCID: https://orcid.org/0000-0003-2702-8823)
- Yuxu Yao (ORCID: https://orcid.org/0000-0002-9783-3951)
- Qingqing Jiao (ORCID: https://orcid.org/0000-0001-6278-2608)
- Xiaolin Bu (ORCID: https://orcid.org/0000-0002-1991-0405)
Institutions
- Second Military Medical University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fmed.2025.1660249
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission