Analysis of the impact of cerebral small vessel disease on neurological outcomes in patients with basal ganglia/corona radiata ischemic stroke treated with intravenous thrombolysis under multimodal MRI guidance

These findings suggest that pre-treatment SVD burden and specific markers-particularly CMBs and DWMHs-may serve as independent predictors of adverse outcomes following IVT in patient patients with basal ganglia or corona radiata infarcts. Furthermore, When all SVD markers are adjusted for simultaneously, only CMBs remained significantly associated with sICH. If validated in prospective studies, the incorporation of rapid, non-invasive SVD assessment into routine pre-IVT imaging protocols could enable more refined individualized risk stratification, supporting informed, patient-centered decision-making regarding treatment risks and benefits while affirming IVT's overall net clinical benefit.