Myeloid PDLIM2 repression as a common mechanism of infection susceptibility in lung diseases
PDLIM2 plays an indispensable role in preventing ALI/ARDS and death, and its repression is associated with COPD and ILD progression. These data suggest that PDLIM2 repression, especially in lung myeloid cells, is a common mechanism driving COPD, ILD/IPF, and lung cancer and increasing patients' susceptibility to infection.
Authors
- Yadong Xiao
- Xujie Liu (ORCID: https://orcid.org/0000-0001-8713-4287)
- Feng Gao (ORCID: https://orcid.org/0000-0001-8764-1107)
- Fan Sun (ORCID: https://orcid.org/0000-0001-8483-152X)
- Zhaoxia Qu (ORCID: https://orcid.org/0000-0002-2769-9814)
- Gutian Xiao
Institutions
- University of Southern California (US)
- Hastings Center (US)
- UPMC Hillman Cancer Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1669117
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Tobacco-Related Disease Research Program
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute of General Medical Sciences