MiR-133a encapsulated in hyaluronic acid nanoparticles alleviates sepsis-induced cardiomyopathy by decreasing M1 macrophage polarization via the SOCS3/JAK/STAT3 pathway
MiR-133a alleviates SIC by inhibiting SOCS3/JAK/STAT3 signaling and promoting M2 polarization. HA-based targeted delivery enhances stability, tissue uptake, and therapeutic efficacy, representing a promising SIC therapy.
Authors
- Xiaohong Huang (ORCID: https://orcid.org/0000-0003-0605-7641)
- Xuehan Wei
- Zheng Chen
- Dan Wu (ORCID: https://orcid.org/0009-0001-1041-6443)
- Yuqiang Gao (ORCID: https://orcid.org/0000-0001-9092-9865)
- Jia Tian
Institutions
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Archives of Biochemistry and Biophysics
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.abb.2025.110673
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00