Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses
Our results suggest that neutrophil dysregulation underpins the high mortality risk conferred by the PERSEVERE-II model. The identified transcriptional regulators may provide potential targets to mitigate neutrophil dysregulation and improve outcomes among high-risk patients.
Authors
- Rishikesan Kamaleswaran (ORCID: https://orcid.org/0000-0001-8366-4811)
- Basilia Zingarelli (ORCID: https://orcid.org/0000-0003-0152-700X)
- Riad Lutfi (ORCID: https://orcid.org/0000-0002-9416-7113)
- Michael T. Bigham (ORCID: https://orcid.org/0000-0002-5085-2231)
- Jennifer Kaplan (ORCID: https://orcid.org/0000-0001-7020-2394)
- Scott L. Weiss (ORCID: https://orcid.org/0000-0002-7040-3281)
- Stephen W. Standage (ORCID: https://orcid.org/0000-0002-0550-6532)
- Timothy E. Sweeney (ORCID: https://orcid.org/0000-0002-3596-1093)
- Mihir R. Atreya (ORCID: https://orcid.org/0000-0002-8302-0984)
- Kelli Harmon
- Bereketeab Haileselassie (ORCID: https://orcid.org/0000-0002-0120-3366)
- Neal J. Thomas (ORCID: https://orcid.org/0000-0002-7991-7510)
- Parag Jain (ORCID: https://orcid.org/0000-0002-2114-2740)
- Andrew J. Lautz (ORCID: https://orcid.org/0000-0003-4922-944X)
- Leland Dunwoodie
- Julie C. Fitzgerald (ORCID: https://orcid.org/0000-0002-7627-1689)
- Natalja L. Stanski (ORCID: https://orcid.org/0000-0003-4473-8376)
- Min Huang (ORCID: https://orcid.org/0000-0001-9019-0044)
- A. R. Moore (ORCID: https://orcid.org/0000-0001-8040-2576)
- Adam J. Schwarz (ORCID: https://orcid.org/0000-0003-0651-8487)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Hospital of Orange County (US)
- Lucile Packard Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- Duke University (US)
- Community Health Systems - Dupont Hospital (US)
- Riley Hospital for Children (US)
- Akron Children's Hospital (US)
- Nemours Children's Health System (US)
- Inflammation Research Foundation (US)
- Stanford Medicine (US)
- Institute of Infection and Immunity (CA)
- Penn State Milton S. Hershey Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- University of Cincinnati Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1663704
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Cincinnati Children's Hospital Medical Center
- National Institutes of Health