The immune receptors TLR4 and SLAMF1 regulate TNF release by human metapneumovirus in human macrophages
Together, our findings identify TLR4 and SLAMF1 as key regulators of early HMPV-induced inflammation via p38 MAPK. SLAMF1 additionally influences IFN-β responses and appears to affect viral replication dynamics. These insights suggest that targeting SLAMF1-TLR4 signaling may offer a therapeutic strategy to limit TNF-driven pathology in HMPV infection.
Authors
- Liv Ryan (ORCID: https://orcid.org/0000-0002-7127-6958)
- Maria Yurchenko (ORCID: https://orcid.org/0000-0002-0516-4747)
- Kristin Rian
- Marit W. Anthonsen
- Terje Espevik
- Katja Sæterhaug Bye
Institutions
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1697494
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Norges Forskningsråd
- HORIZON EUROPE Framework Programme