The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model
A single administration of IL-35 shortly after mating, does not have an anti-abortion effect. It exhibits a multifaceted effect on immune regulatory cells and IL-35 neutralization results in decreased embryonic heart rate and impaired placental-fetal circulation.
Authors
- Anna Chełmońska‐Soyta (ORCID: https://orcid.org/0000-0001-7360-3257)
- A Kedzierska (ORCID: https://orcid.org/0000-0002-0804-2710)
- Anna Sławek (ORCID: https://orcid.org/0000-0002-5103-138X)
- Mateusz Psurski (ORCID: https://orcid.org/0000-0001-8866-7149)
- Paulina Kubik (ORCID: https://orcid.org/0000-0002-7502-4627)
Institutions
- Wrocław University of Environmental and Life Sciences (PL)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1648641
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00