Prognostic significance of the lymphocyte-to-high-density lipoprotein ratio in long-term efficacy of combined immunotherapy for advanced non-small cell lung cancer
This study demonstrated that the lymphocyte-to-high-density lipoprotein ratio (LHR) is an independent predictor of long-term outcomes in patients with advanced NSCLC receiving chemo-immunotherapy. A low LHR was associated with improved progression-free survival, overall survival, and higher objective response and disease control rates. The nomogram model incorporating LHR showed favorable predictive accuracy and clinical applicability.
Authors
- Guijuan Ji
- Zhiyuan Yao (ORCID: https://orcid.org/0009-0009-1920-236X)
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-7953-1845)
- Yingnan Zhang (ORCID: https://orcid.org/0000-0002-2070-6786)
- Wenwen Guo (ORCID: https://orcid.org/0000-0001-8563-0359)
- Yuan Zhang (ORCID: https://orcid.org/0000-0003-0527-6017)
- Gaolei Ma
- Lijie Ma
Institutions
- Xuzhou Medical College (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Xuzhou No.1 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fonc.2025.1712779
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00