Case Report: REM sleep without atonia in an adult with pediatric acute-onset neuropsychiatric syndrome: a case study and mechanistic insights
RSWA may represent an under-recognized manifestation of chronic neuroimmune dysfunction in PANS. Its persistence into adulthood suggests long-term dysregulation of REM sleep circuitry and invites further investigation into the role of orexin and basal ganglia-mediated inhibition in neuroimmune disorders.
Authors
- Monica Puligheddu (ORCID: https://orcid.org/0000-0002-6837-6608)
- David John O'Regan (ORCID: https://orcid.org/0000-0002-3809-022X)
- Nazanin Biabani (ORCID: https://orcid.org/0009-0003-8432-1310)
- Neepa Gurbani (ORCID: https://orcid.org/0000-0003-3354-2853)
- Katarina Ilić (ORCID: https://orcid.org/0000-0002-8995-6396)
- Ivana Rosenzweig (ORCID: https://orcid.org/0000-0003-2152-9694)
- Danielle Wasserman (ORCID: https://orcid.org/0000-0002-4150-7831)
- Valentina Gnoni (ORCID: https://orcid.org/0000-0003-3181-0842)
- Joshua Benson (ORCID: https://orcid.org/0000-0003-2565-8338)
- Alexander Nesbitt (ORCID: https://orcid.org/0000-0002-1979-8003)
- Philip R. Holland (ORCID: https://orcid.org/0000-0003-3345-4853)
- Panagis Drakatos (ORCID: https://orcid.org/0000-0002-8298-7878)
- Martina Mulas (ORCID: https://orcid.org/0009-0008-3827-4150)
- Seán Higgins
- Ana Santic
- Karolina Poplewska
Institutions
- Poznan University of Medical Sciences (PL)
- University of Cagliari (IT)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Shaare Zedek Medical Center (IL)
- Klinika za psihijatriju Vrapče (HR)
- King's College Hospital (GB)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Frontiers in Sleep
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/frsle.2025.1654119
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- King's College London