The global, regional, and national burden of colorectal cancer and its attributable risk factors in 204 countries and territories, 1990-2021: a systematic analysis for the global burden of disease study 2021

From 1990 to 2021, the global CRC burden increased significantly, with notable variations across SDI regions. While high SDI regions made progress in reducing mortality and DALYs, low SDI regions now face a heavier burden. Targeted interventions for modifiable risk factors and improved healthcare access in less developed regions are essential to mitigate the global impact of CRC.