Correlation study between serum uric acid level and cognitive impairment in middle-aged and elderly patients with hypertension: based on an explainable predictive model
SUA has a certain correlation with MCI in the middle-aged and elderly hypertensive populations. Although SUA is considered as a neuroprotective agent, its neuroprotective function gradually diminishes and may even become detrimental when SUA higher than a threshold. These results suggest maintaining SUA within an optimal range may help mitigate MCI risk in hypertensive populations.
Authors
- Qin‐Fen Chen (ORCID: https://orcid.org/0000-0001-6596-5004)
- Juan Du (ORCID: https://orcid.org/0000-0001-5430-5385)
- Zheng Ping (ORCID: https://orcid.org/0000-0002-9056-1826)
- Xiaoyun Zhang (ORCID: https://orcid.org/0000-0002-2572-0229)
- Jiarui Wang (ORCID: https://orcid.org/0000-0003-0301-5016)
- Jiajia Hu (ORCID: https://orcid.org/0000-0002-6221-8748)
- Yihong Huang (ORCID: https://orcid.org/0000-0002-9962-3632)
- Di Wu (ORCID: https://orcid.org/0000-0003-4961-9624)
- Dongxu Lu
- Hetong Liao
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Chinese PLA General Hospital (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
- Beijing Institute of Water (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fneur.2025.1708305
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00