Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling
<i>Cept1</i> overexpression promotes EC function and postischemic recovery. The impact of CEPT1 on ECs is at least in part dependent on p-Akt/p-eNOS angiogenic signaling and PPARα. Because CEPT1 is elevated in diseased human peripheral arterial tissue, these findings suggest that CEPT1 may be playing an important compensatory role in vascular recovery and reperfusion following ischemic injury in the setting of diabetes.
Authors
- Tariq Jamal Khan (ORCID: https://orcid.org/0000-0001-8909-8427)
- Santiago Elizondo Benedetto (ORCID: https://orcid.org/0000-0002-0911-8086)
- Mohamed A. Zayed (ORCID: https://orcid.org/0000-0001-6443-4527)
- Tiandao Li (ORCID: https://orcid.org/0000-0003-1650-0555)
- Fong‐Fu Hsu (ORCID: https://orcid.org/0000-0001-5368-0183)
- Brigida Rusconi (ORCID: https://orcid.org/0000-0001-8422-122X)
- Batool Arif (ORCID: https://orcid.org/0009-0006-3610-0865)
- Omar Saffaf
- Clay F. Semenkovich (ORCID: https://orcid.org/0000-0003-1163-1871)
- Sangeeta Adak (ORCID: https://orcid.org/0000-0003-3855-9099)
- Rodrigo Meade
- Larisa Belaygorod
- Bo Zhang (ORCID: https://orcid.org/0000-0003-2962-5314)
- Mohamed S. Zaghloul (ORCID: https://orcid.org/0009-0008-4682-0932)
Institutions
- Washington University in St. Louis (US)
- VA St. Louis Health Care System (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1161/atvbaha.125.323302
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00