Six-methoxyflavone suppresses CircPIAS1 biogenesis via targeting PTBP1 and, in combination with IFN-γ, promotes ferroptosis in melanoma
6-MF targets <i>PTBP1</i> to inhibit circPIAS1 biogenesis and reduce circPIAS1-108aa.6-MF inhibits PI3K-AKT pathway; combined with IFN-γ, it enhances <i>STAT1</i> phosphorylation, inhibits <i>SLC7A11/GPX4</i> pathway, promoting melanoma ferroptosis. Its combination with PD-1 inhibitor enhances antitumor efficacy, providing a novel therapeutic strategy for melanoma treatment.
Authors
- Meng‐Yue Wang
- Yuan‐Zheng Xia (ORCID: https://orcid.org/0000-0002-8526-5184)
- Cheng-mei Xiao
- Xin Zang
- Hui Hou (ORCID: https://orcid.org/0000-0001-8974-197X)
- Chengyan Liu (ORCID: https://orcid.org/0000-0001-7411-8069)
- Ye Guo (ORCID: https://orcid.org/0009-0009-3512-9000)
- Xi Wu (ORCID: https://orcid.org/0000-0002-9442-5856)
- Ling‐Yi Kong (ORCID: https://orcid.org/0000-0002-4791-8615)
- Lifang Zhang
Institutions
- China Pharmaceutical University (CN)
- Soochow University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.3389/fphar.2025.1681890
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lishui University